 |
References
Ganaxolone Seizure Disorders
- Biagini, G., et al. 2006. Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy. Exp Neurol 201, 519-524.
- Biagini, G., et al., 2009. Neurosteroids and epileptogenesis in the pilocarpine model: Evidence for a relationship between P450scc induction and length of the latent period. Epilepsia 50(Suppl. 1), 53-58.
- Bialer M., et al., 2010. Progress report on new antiepileptic drugs: A summary of the Tenth Eilat Conference (EILAT X). Epilepsy Res, 92, 89-124.
- Carter, R.B., et al., 1997. Characterization of the anticonvulsant properties of ganaxolone (CCD 1042;3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acidA receptor. J Pharmacol Exp Ther 280, 1284-1295.
- Herd, M.B., et al., 2007. Neurosteroid modulation of synaptic and extrasynaptic GABAA receptors. Pharmacol Ther 116, 20-34.
- Hosie, A.D., et al., 2006. Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites. Nature 444, 486-489
- Kaminski, R. M., et al., 2003.Protective efficacy of neuroactive steroids against cocaine kindled-seizures in mice. Eur J Pharmacol 474, 217-22.
- Kaminski, R.M., et al., 2004. Allopregnanolone analogs that positively modulate GABAA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice. Epilepsia 45, 864-867.
- Kerrigan, J. F., et al., 2000. Ganaxolone for treating intractable infantile spasms: a multicenter, open-label, add-on trial. Epilepsy Res 42, 133-139.
- Lemos, T., Cavalheiro, E.A., 1995. Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats. Exp Brain Res 102, 423-428.
- Leśkiewicz, M., et al., 2003. Inhibitory effect of some neuroactive steroids on cocaine-induced kindling in mice. Pol J Pharmacol 55, 1131-1136.
- Liptáková, S., et al., 2000. Effect of ganaxolone on flurothyl seizures in developing rats. Epilepsia 41, 788-793.
- Nohria, V., Giller, E., 2007. Ganaxolone. Neurotherapeutics 4, 102-105.
- Pieribone, V.A., et al., 2007. Clinical evaluation of ganaxolone in pediatric and adolescent patients with refractory epilepsy. Epilepsia 48, 1870-1874.
- Reddy, D.S., Rogawski, M.A., 2000. Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself. J Pharmacol Exp Ther 295, 1241-1248.
- Reddy, D.S., Rogawski, M.A., 2010. Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model. Epilepsy Res doi:10.1016/j.eplepsyres.2010.01.009.
|